| Autor: |
Elisabete Nascimento-Gonçalves, Fernanda Seixas, Carlos Palmeira, Gabriela Martins, Carolina Fonseca, José Alberto Duarte, Ana I. Faustino-Rocha, Bruno Colaço, Maria João Pires, Maria João Neuparth, Daniel Moreira-Gonçalves, Margarida Fardilha, Magda C. Henriques, Daniela Patrício, Steven Pelech, Rita Ferreira, Paula A. Oliveira |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
GeroScience. |
| ISSN: |
2509-2723 |
| Popis: |
This work aimed to understand how lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of PCa. Fifty-five male Wistar rats were divided into four groups: control sedentary, control exercised, induced PCa sedentary and induced PCa exercised. Exercised animals were trained in a treadmill for 53 weeks. Pca induction consisted on the sequential administration of flutamide, N-methyl-N-nitrosourea and testosterone propionate implants. Serum concentrations of C-reactive protein (CRP) and tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) were not different among groups. Peripheral levels of γδ T cells were higher in Pca exercised group than in the PCa sedentary group (p |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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