Influence of quipazine, a potential anti-parkinsonian agent on the uptake of 3H-dopamine and 3H-serotonin into rat striatal tissue in vitro
| Autor: | Philip J. Medon, Jerry L. Leeling, Barrie M. Phillips |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
medicine.medical_specialty
Serotonin uptake Chemistry Quipazine Dopaminergic Central nervous system General Medicine Pharmacology Serotonergic General Biochemistry Genetics and Molecular Biology In vitro Endocrinology medicine.anatomical_structure Dopamine Internal medicine medicine Serotonin General Pharmacology Toxicology and Pharmaceutics medicine.drug |
| Zdroj: | Life Sciences. 13:685-691 |
| ISSN: | 0024-3205 |
| DOI: | 10.1016/0024-3205(73)90285-3 |
| Popis: | Quipazine (2-(1-piperazinyl)quinoline maleate), an agent with anti-tremorine and serotonin-like activity, was found to inhibit the uptake of 3 H-dopamine and 3 H-serotonin into rat striatal tissue in vitro . Quipazine was shown to be three times more effective as an inhibitor of serotonin uptake than dopamine uptake, the IC 50 's being 2.98 × 10 −5 M and 1.00 × 10 −4 M, respectively. These data suggest that quipazine exerts serotonergic and dopaminergic effects in the central nervous system. |
| Databáze: | OpenAIRE |
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