An Improved Route for the Synthesis of Guanine Quadruplex Ligand Phen-DC3

Autor:	Caitlin E. Miron, Anne Petitjean
Rok vydání:	2018
Předmět:	010405 organic chemistry Guanine Ligand Organic Chemistry RNA Alkylation 010402 general chemistry 01 natural sciences Small molecule Combinatorial chemistry 0104 chemical sciences chemistry.chemical_compound chemistry Yield (chemistry) Selectivity DNA
Zdroj:	Synlett. 29:1362-1366
ISSN:	1437-2096 0936-5214
Popis:	The recognition of noncanonical DNA and RNA architectures such as guanine quadruplexes by small molecule ligands has become a promising strategy for anticancer and antiviral applications in recent years, leading to an exponential increase in the number of quadruplex ligands reported in the literature. There is consequently a need for ‘benchmark’ compounds which can be used as controls to facilitate comparisons between novel and previously reported ligands. One candidate for this role is Phen-DC3, which binds with high affinity and selectivity to guanine quadruplexes. To encourage its use in this role, an alternate synthetic route for the production of Phen-DC3 that may be more appropriate for implementation on a large scale is reported. This pathway eliminates the need for several hazardous reagents and increases the overall synthetic yield from 21% to a maximum of 43%.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::10776d00ce72ae2f995acc7ca3b4a45f https://doi.org/10.1055/s-0036-1591994 Zobrazit plný text záznamu