Increases in CD3+CD4-CDS- T Lymphocytes in AIDS Patients with Disseminated Mycobacterium avium-intracellulare Complex Infection

Autor:	Jean-Luc Pellegrin, Michel Dupon, Catherine Marimoutou, P. Barbeau, Marc Bonneville, Noëlle Bernard, Jean-François Moreau, Jean-Luc Taupln, Valérie Journot, Jean-Claude Carron, Joël Constans, Jeannette Texier-Maugein, Jean-Marie Ragnaud, François Dabis
Rok vydání:	1996
Předmět:	biology T cell CD3 T-cell receptor T lymphocyte Virology Interleukin 21 Infectious Diseases medicine.anatomical_structure Antigen Immunology medicine biology.protein Immunology and Allergy Gamma delta T cell CD8
Zdroj:	Journal of Infectious Diseases. 174:969-976
ISSN:	1537-6613 0022-1899
Popis:	Human immunodeficiency virus type 1 (HIV-1)-infected persons frequently have increased numbers of T cells bearing the gamma delta T cell receptor for antigen (gamma delta TCR). HIV-1-seropositive patients with < 100 CD4+ cells/mm3 were selected and divided into 9 AIDS-defining illness groups. The percentages of CD4+, CD8+, or double-negative CD4-CD8- (DN) T cells (most of the latter expressing the gamma delta TCR) for 8 symptomatic groups were compared with those for a reference group of asymptomatic HIV-1-infected patients. DN T cells were increased only in patients with disseminated Mycobacterium avium-intracellulare complex (MAC) infection, toxoplasmosis, or Kaposi's sarcoma. Multivariate logistic regression analysis revealed that the percentage of DN T cells was a better predictor of MAC infection than was the percentage of CD4+T cells. The increased percentage of DN T cells might have important implications for the understanding of gamma delta T cell physiology and for the early diagnosis and management of MAC infections in AIDS patients.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1076433b6733c653eda176515229dc77 https://doi.org/10.1093/infdis/174.5.969 Zobrazit plný text záznamu