Rare complete loss of function provides insight into a pleiotropic genome-wide association study locus

Autor:	Mugdha Joshi, Kyriacos Markianos, Akshat Agrawal, Vijay G. Sankaran, Klaus Schmitz-Abe, Gerard T. Berry, Meghan C. Towne, Pankaj B. Agrawal, Nicholas S. Marinakis
Rok vydání:	2013
Předmět:	Genetics Immunology Locus (genetics) Genome-wide association study Cell Biology Hematology Biology Biochemistry Red blood cell medicine.anatomical_structure Intergenic region Fetal hemoglobin medicine MYB Loss function Genetic association
Zdroj:	Blood. 122:3845-3847
ISSN:	1528-0020 0006-4971
DOI:	10.1182/blood-2013-09-528315
Popis:	To the editor: Recent genome-wide association studies (GWASs) of hematological traits have consistently found strong associations between the HBS1L - MYB intergenic region on 6q23 and a number of clinically significant hematologic traits, including fetal hemoglobin (HbF) levels, red blood cell
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::107459ee4ca3301b0428899d0032f944 https://doi.org/10.1182/blood-2013-09-528315 Zobrazit plný text záznamu