Psychological and mental health problems in patients with thalidomide embryopathy in Japan

Autor:	Yuko Nukui, Toshiharu Iida, Maki Yamamoto, Koubun Imai, Atsuto Yoshizawa, Kensuke Komatsu
Rok vydání:	2014
Předmět:	medicine.medical_specialty General Neuroscience Wechsler Adult Intelligence Scale Cognition General Medicine Mental health Thalidomide Psychiatry and Mental health Neurology medicine Anxiety Psychological testing Neurology (clinical) Effects of sleep deprivation on cognitive performance medicine.symptom Psychology Psychiatry Clinical psychology medicine.drug Mini-international neuropsychiatric interview
Zdroj:	Psychiatry and Clinical Neurosciences. 68:479-486
ISSN:	1323-1316
DOI:	10.1111/pcn.12152
Popis:	Aim The aim of the study was to examine the presence of psychological and mental health problems in patients with thalidomide embryopathy in Japan in order to develop and build future support systems. Methods The present study examined the presence/absence of electroencephalographic abnormalities, intellectual/cognitive functions, and mental health problems in 22 participants (nine men, 13 women) with thalidomide embryopathy. Participants completed the electroencephalograph instrument. Participants were also assessed using the Wechsler Adult Intelligence Scale-III; the Autism-Spectrum Quotient; the General Health Questionnaire-28, and the Mini-International Neuropsychiatric Interview. Results The results suggest the following: (i) electroencephalographic abnormality observed in several thalidomide embryopathy participants is unlikely to be the direct result of thalidomide; (ii) the cognitive functions of working memory and processing speed are lower in thalidomide embryopathy patients than in healthy individuals; and (iii) 40.9% of the thalidomide embryopathy participants have possible mental disorders, with more mental problems observed than in healthy individuals. Conclusions Deterioration of mental health in patients with thalidomide embryopathy is indicated. Anxiety, insomnia, and physical symptoms were especially remarkable and may have resulted in restriction of social activities. Therefore, careful examination and active support of patients' psychological and mental problems is essential.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1070f079a907a755c399a5568e88c2c8 https://doi.org/10.1111/pcn.12152 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.