Absence of Relationship between Serum Vitamin D Levels, Degree of Hepatic Fibrosis, and Virologic Response to Pegylated Interferon and Ribavirin Therapy in Patients with Chronic Hepatitis C
| Autor: | João Luiz Rodrigues De Farias, Edison Roberto Parise, Lívia Zardo Trindade, Patricia Souza de Almeida Borges, Ibrahim Ahmad H. El Bacha, Roberto J. Carvalho-Filho, Vivian Mota Guimarães |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Combination therapy Serum albumin Gastroenterology vitamin D deficiency 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Pegylated interferon Fibrosis Internal medicine medicine Hepatology medicine.diagnostic_test biology business.industry Ribavirin medicine.disease 030104 developmental biology chemistry Liver biopsy Immunology biology.protein 030211 gastroenterology & hepatology business Viral load medicine.drug |
| Zdroj: | Journal of Gastroenterology and Hepatology Research. 5:2015-2020 |
| ISSN: | 2224-3992 |
| DOI: | 10.17554/j.issn.2224-3992.2016.05.613 |
| Popis: | Introduction: In patients with chronic hepatitis C virus (HCV) infection, 25-hydroxyvitamin D3 [25(OH)D] deficiency has been associated with disease progression and decreased odds of sustained virologic response (SVR) to pegylated interferon and ribavirin combination therapy (PegIFN+RBV). Methods: In this retrospective study, the pretreatment 25(OH)D levels of patients with genotype 1 HCV infection treated with PegIFN + RBV for 48 weeks were measured and correlated with disease stage and periportal necroinflammatory activity (PPA) on liver biopsy, as well as to virologic response at the end of the treatment period. Serum 25(OH)D levels were quantitated by chemiluminescence. Results: Of the 201 patients included, 53% were male and 70% were white, with a mean (SD) age of 46 (±11) years. Subtype 1b was identified in 48% of cases, and 57% of patients had a viral load over 800,000 IU/mL. Overall, 29% of patients had stage 3/4 fibrosis and 40% had grade 3/4 PPA. SVR was achieved in 47% of patients. The mean 25(OH)D concentration was 26.3 (±11.5) ng/mL. Low 25(OH)D levels ( |
| Databáze: | OpenAIRE |
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