Anti-obesity effect of robusta fermented with Leuconostoc mesenteroides in high-fat diet-induced obese mice
| Autor: | Ji‑Young Shin, Inn Goo Kyeong, Hee Yeon Jeon, Jin Il Park, Seung Hoon Ham, Jong Hyung Park, Seung Hyun Ryu, Jun-Young Kim, Soo-Young Choi, Eui Suk Jeong, Yang-Kyu Choi, Dong‑Goo Kim |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.medical_specialty 030109 nutrition & dietetics Fatty acid metabolism biology Adipose tissue Lipid metabolism General Medicine medicine.disease biology.organism_classification Obesity Sterol 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology Endocrinology Immunology and Microbiology (miscellaneous) chemistry Leuconostoc mesenteroides Apoptosis Internal medicine Diabetes mellitus Immunology medicine |
| Zdroj: | Experimental and Therapeutic Medicine. 14:3761-3767 |
| ISSN: | 1792-1015 1792-0981 |
| DOI: | 10.3892/etm.2017.4990 |
| Popis: | Robusta beans cultivated with Monascus ruber (RMR) were successively fermented with Leuconostoc mesenteroides (LM) and the antiobesity effects were examined. To produce an obese mouse model to investigate the hypolipidemic effects, ICR mice were fed the same high-fat diet for 6 weeks. Treatment groups were given 10 or 20% RMR-LM. Body weight changes in the 20% RMR-LM group were lower compared with those in the control group. Visceral adipose tissue weight and adipose size were significantly lower in the 20% RMR-LM group compared with those in the control group. Significant improvement in glucose tolerance was observed in the 10 and 20% RMR-LM groups compared with the control group. The 20% RMR-LM group exhibited a significant reduction in serum glucose concentration. Hepatic mRNA levels of sterol regulatory element-binding protein 1, fas cell surface death receptor, and peroxisome proliferator-activated receptor γ, which are associated with lipid, and fatty acid metabolism, in the 20% RMR-LM group were significantly lower compared with those in the control group. The results of the present study demonstrated that 20% RMR-LM may be used to prevent obesity, and ameliorate diabetes and lipid metabolism imbalances. |
| Databáze: | OpenAIRE |
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