Three Months versus One Year of Oral Anticoagulant Therapy for Idiopathic Deep Venous Thrombosis
| Autor: | Giancarlo Agnelli, Paolo Prandoni, Maria Gabriella Santamaria, Paola Bagatella, Alfonso Iorio, Mario Bazzan, Marco Moia, Giuliana Guazzaloca, Adriano Bertoldi, Cristina Tomasi, Gianluigi Scannapieco, Alessandra Ascani, Sabina Villalta, Michela Frulla, Laura Mosena, Antonio Girolami, Antonella Vaccarino, Adriano Alatri, Gualtiero Palareti, Mario Marchesi, Giovanni Battista Ambrosio, Roberto Parisi, Silvia Doria, Luigi Steidl, Fabio Ambrosini, Mauro Silingardi, Angelo Ghirarduzzi, Ido Iori, Walter Ageno |
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| Rok vydání: | 2001 |
| Předmět: | |
| Zdroj: | New England Journal of Medicine. 345:165-169 |
| ISSN: | 1533-4406 0028-4793 |
| DOI: | 10.1056/nejm200107193450302 |
| Popis: | Background In patients with idiopathic deep venous thrombosis, continuing anticoagulant therapy beyond three months is associated with a reduced incidence of recurrent thrombosis during the period of therapy. Whether this benefit persists after anticoagulant therapy is discontinued is controversial. Methods Patients with a first episode of idiopathic proximal deep venous thrombosis who had completed three months of oral anticoagulant therapy were randomly assigned to the discontinuation of oral anticoagulants or to their continuation for nine additional months. The primary study outcome was recurrence of symptomatic, objectively confirmed venous thromboembolism during at least two years of follow-up. Results The primary intention-to-treat analysis showed that of 134 patients assigned to continued oral anticoagulant therapy, 21 had a recurrence of venous thromboembolism (15.7 percent; average follow-up, 37.8 months), as compared with 21 of 133 patients assigned to the discontinuation of oral anticoagulant ... |
| Databáze: | OpenAIRE |
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