Assessment of bone morphogenic protein and hydroxyapatite–titanium dioxide composites for bone implant materials
| Autor: | Hsien-Te Chen, Chi-Jen Chung, Ju-Liang He, Hui-Ying Shu |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
animal structures
Materials science technology industry and agriculture chemistry.chemical_element Surfaces and Interfaces General Chemistry engineering.material Condensed Matter Physics Bone morphogenetic protein Surfaces Coatings and Films chemistry.chemical_compound stomatognathic system chemistry Coating embryonic structures Bone cell Titanium dioxide Materials Chemistry engineering Alkaline phosphatase Composite material Cell adhesion Filopodia Titanium |
| Zdroj: | Surface and Coatings Technology. 276:168-174 |
| ISSN: | 0257-8972 |
| DOI: | 10.1016/j.surfcoat.2015.06.056 |
| Popis: | The HAp–TiO 2 coating, made by micro-arc oxidation (MAO), is successfully grown on the Ti surface in one step; BMP-2 growth factor is physically immobilized on the HAp–TiO 2 coating. The BMP-2/HAp–TiO 2 hybrid system outperforms systems of pure Ti, BMP-2/Ti, and HAp–TiO 2 by promoting cell adhesion increasing filopodia and polygonal lamellipodia extension, and increasing cell viability. Additionally, cell proliferation and alkaline phosphatase (ALP) activity both indicate that the BMP-2/HAp–TiO 2 hybrid system is more successful. According to the characteristics of mechanical support from HAp–TiO 2 , the BMP-2/HAp–TiO 2 hybrid system can maintain a stable release rate of BMP-2 to promote bone cell growth and rapidly heal the bone–implant interface. The new BMP-2/HAp–TiO 2 hybrid system developed in this study can be expected to contribute in the application of orthopedic and dental implants. |
| Databáze: | OpenAIRE |
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