Effect of administration of oral contraceptives on the synthesis and breakdown of myofibrillar proteins in young women
| Autor: | Todd A. Trappe, Mette Hansen, Simon Doessing, Lars Holm, Susanne Germann Petersen, Dorthe Skovgaard, Henning Langberg, Michael Kjaer, Benjamin F. Miller |
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| Rok vydání: | 2011 |
| Předmět: |
education.field_of_study
medicine.medical_specialty business.industry Population Protein turnover Skeletal muscle Physical Therapy Sports Therapy and Rehabilitation musculoskeletal system Protein catabolism Endocrinology medicine.anatomical_structure Interstitial fluid Internal medicine medicine Orthopedics and Sports Medicine Androstenedione education Myofibril business Testosterone |
| Zdroj: | Scandinavian Journal of Medicine & Science in Sports. 21:62-72 |
| ISSN: | 0905-7188 |
| DOI: | 10.1111/j.1600-0838.2009.01002.x |
| Popis: | Oral contraceptive (OC) treatment has an inhibiting effect on protein synthesis in tendon and muscle connective tissue. We aimed to investigate whether OC influence myofibrillar protein turnover in young women. OC-users (24±2 years; Lindynette® n=7, Cilest® n=4) and non-OC-users (controls, 24±4 years n=12) performed one-legged kicking exercise. The next day, the myofibrillar protein fractional synthesis rate (FSR) was measured using stable isotopic tracers ((13)C-proline) while the subjects were fed standardized nutrient drinks. Simultaneously, a marker for myofibrillar protein breakdown, 3-methyl-histidine (3-MH), was measured in the interstitial fluid of the vastus lateralis. Measurements were performed in both legs. In general, myofibrillar protein FSR was lower in OC-users (two-way analysis of variance, P |
| Databáze: | OpenAIRE |
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