| Autor: |
Rebeca Santano, Evelina Angov, Ross L. Coppel, Chauhan, Bin Zhan, Escola, Demontis M, Jose Muñoz, Jorge Cano, Pau Cisteró, Chetan E. Chitnis, Inocencia Cuamba, van Lieshout L, Gemma Ruiz-Olalla, Deepak Gaur, Gemma Moncunill, Anelsio Cossa, David R. Cavanagh, Ruth Aguilar, Carlota Dobaño, Jose Carlos Jamine, Berta Grau-Pujol, Rocío Rubio, Charfudin Sacoor, Marta Vidal, Muchisse O, Sheetij Dutta, Luis Izquierdo |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
Coinfection withPlasmodium falciparumand helminths may impact the immune response to these parasites since they induce different immune profiles. We studied the effects of coinfections on the antibody profile in a cohort of 715 Mozambican children and adults using the Luminex technology with a panel of 16 antigens fromP. falciparumand 11 antigens from helminths (Ascaris lumbricoides, hookworm,Trichuris trichiura,Strongyloides stercoralisandSchistosomaspp.) and measured antigen-specific IgG and total IgE responses. We compared the antibody profile between groups defined byP. falciparumand helminth previous exposure (based on serology) and/or current infection (determined by microscopy and/or qPCR). In multivariable regression models adjusted by demographic, socioeconomic, water and sanitation variables, individuals exposed/infected withP. falciparumand helminths had significantly higher total IgE and antigen-specific IgG levels, magnitude (sum of all levels) and breadth of response to both types of parasites compared to individuals exposed/infected with only one type of parasite (p≤ 0.05). There was a positive association between exposure/infection toP. falciparumand exposure/infection to helminths or the number of helminth species, andvice versa(p≤ 0.001). In addition, children coexposed/coinfected tended (p= 0.062) to have higherP. falciparumparasitemia than those single exposed/infected. Our results suggest that an increase in the antibody responses in coexposed/coinfected individuals may reflect higher exposure and be due to a more permissive immune environment to infection in the host.GRAPHICAL ABSTRACT |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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