Influence of high dietary sodium intake on the functional subtypes of α1-adrenoceptors in the renal cortical vasculature of Wistar-Kyoto rats
| Autor: | Nor Aniza Abdullah, Edward J. Johns, Abdul Hye Khan, A. S. Munavvar, Raisa N. Kazi |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Pharmacology
medicine.medical_specialty business.industry Antagonist Alpha (ethology) Adrenergic Methoxamine chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Chloroethylclonidine Internal medicine medicine Vascular resistance medicine.symptom business Phenylephrine Vasoconstriction medicine.drug |
| Zdroj: | Autonomic and Autacoid Pharmacology. 29:25-31 |
| ISSN: | 1474-8673 1474-8665 |
| DOI: | 10.1111/j.1474-8673.2009.00428.x |
| Popis: | 1 Increased renal vascular resistance is one renal functional abnormality that contributes to hypertension, and alpha(1)-adrenoceptors play a pivotal role in modulating this renal vascular resistance. This study investigates the functional contribution of alpha(1)-adrenoceptor subtypes in the renal cortical vasculature of Wistar-Kyoto rats on a normal sodium diet (WKYNNa) compared with those given saline to drink for 6 weeks (WKYHNa). 2 The renal cortical vascular responses to the adrenergic agonists noradrenaline (NA), methoxamine (ME) and phenylephrine (PE) were measured in WKYHNa and WKYNNa rats either in the absence (the control phase) or presence of chloroethylclonidine (CEC), an alpha(1B)-adrenoceptor antagonist, 5-methylurapidil (5-MeU), an alpha(1A) antagonist, or BMY7378, an alpha(1D) antagonist. 3 Results showed a greater renal cortical vascular sensitivity to NA, PE and ME in the WKYHNa compared with WKYNNa rats (P < 0.05). Moreover, 5-MeU and BMY7378 attenuated adrenergically induced renal cortical vasoconstriction in WKYHNa and WKYNNa rats; this response was largely blunted in CEC-treated WKYHNa rats (all P < 0.05) but not in CEC-treated WKYNNa rats. 4 The data suggest that irrespective of dietary sodium content, in Wistar-Kyoto rats alpha(1A)- and alpha(1D)-subtypes are the major alpha(1)-adrenoceptors in renal cortical vasculature; however, there appears to be a functional involvement of alpha(1B)-adrenoceptors in the WKYHNa rats. |
| Databáze: | OpenAIRE |
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