Characterization of β-cyclodextrin-diminazene Aceturate Complex Used to Treat Ichthyophthirius multifiliis Infection in Common Carp
| Autor: | Andrei-Cristian Lupu, Simona Ciobotarescu, Elena-Luiza Epure, Liviu Miron, Gabriela Lisa, Nicolae Hurduc |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
chemistry.chemical_classification
Process equipment Ichthyophthirius multifiliis biology Cyclodextrin Chemistry Materials Science (miscellaneous) Process Chemistry and Technology General Engineering General Chemistry General Medicine biology.organism_classification General Biochemistry Genetics and Molecular Biology Microbiology Common carp Materials Chemistry Diminazene aceturate General Pharmacology Toxicology and Pharmaceutics |
| Zdroj: | Revista de Chimie. 71:90-101 |
| ISSN: | 2668-8212 0034-7752 |
| DOI: | 10.37358/rc.20.3.7977 |
| Popis: | This study was carried out to explore the efficacy of a veterinary drug, diminazene aceturate (DA) (4,4�-(1-triazene-1,3- dyil)bis-benzenecarboximidamide), in an inclusion complex with β-cyclodextrin (β-CD) as a suitable treatment for parasitic disease caused by Ichthyophthirius multifiliis in farmed carp. The efficacy was determined by the reduction in the infection intensity. The complexes were characterized through thermogravimetric analysis and molecular modeling. The selected stoichiometry for the chosen drug was 1:1. The geometry of inclusion complexes has been investigated by molecular modeling at semi-empirical level in order to find the most favourable structure. Administration of DA in its simple form and included in β-CD was carried out by embedding appropriate doses in the animal feed. Our studies suggest that when DA was used in the complex structure, a reduction in the infection degree and decrease in the trophont size in the treated fish was observed. From these first results of our study, the oral treatment with the complex of DA included in β-CD(DA�β-CD) is found to be a suitable alternative to bath treatments in carp diseases. |
| Databáze: | OpenAIRE |
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