Synthesis and biological evaluation of novel 2-vinyl carbapenems. Remarkable DHP-1 stability of 1′-substituted analogs

Autor:	Satoru Kuroda, Kazuo Sakane, Kouji Hattori, Akira Yamada, Toshiaki Kamimura, Toshiyuki Chiba
Rok vydání:	1996
Předmět:	endocrine system Chemistry Organic Chemistry Clinical Biochemistry Pharmaceutical Science biochemical phenomena metabolism and nutrition Biochemistry Combinatorial chemistry Drug Discovery polycyclic compounds Molecular Medicine Moiety Antibacterial activity Molecular Biology Biological evaluation
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 6:2705-2708
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(96)00495-7
Popis:	The synthesis antibacterial activity and DHP-susceptibility of a series of novel 2-vinyl carbapenems is described. Carbapenems having a 1′-substituted vinyl moiety at the 2 position were found to be very stable toward DHP-1, displaying comparable stability to compounds with a 1β-methyl functionality.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1040d6105ab2e9160b256293b267cafc https://doi.org/10.1016/s0960-894x(96)00495-7 Zobrazit plný text záznamu Full Text from ScienceDirect