Noninvasive Blood Glucose Assay by Near-Infrared Diffuse Reflectance Spectroscopy of the Human Inner Lip
| Autor: | F. A. Gries, Th. Koschinsky, H. M. Heise, Ralf Marbach |
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| Rok vydání: | 1993 |
| Předmět: |
0301 basic medicine
education.field_of_study Diffuse reflectance infrared fourier transform Capillary action Chemistry Near-infrared spectroscopy Population Analytical chemistry Venous blood 030204 cardiovascular system & hematology 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Linear regression Calibration Diffuse reflection education Instrumentation Spectroscopy |
| Zdroj: | Applied Spectroscopy. 47:875-881 |
| ISSN: | 1943-3530 0003-7028 |
| DOI: | 10.1366/0003702934415354 |
| Popis: | Near-infrared (NIR) spectra of the human inner lip were obtained by using a special optimized accessory for diffuse reflectance measurements. The partial-least squares (PLS) multivariate calibration algorithm was applied for linear regression of the spectral data between 9000 and 5500 cm−1 (Λ = 1.1–1.8 μm) against blood glucose concentrations determined by a standard clinical enzymatic method. Calibration experiments with a single person were carried out under varying conditions, as well as with a population of 133 different patients, with capillary and venous blood glucose concentration values provided. A genuine correlation between the blood glucose concentrations and the NIR-spectra can be proven. A time lag of about 10 min for the glucose concentration in the spectroscopically probed tissue volume vs. the capillary concentration can be estimated. Mean-square prediction errors obtained by cross-validation were in the range of 45 to 55 mg/dL. An analysis of different variance factors showed that the major contribution to the average prediction uncertainty was due to the reduced measurement reproducibility, i.e., variations in lip position and contact pressure. The results demonstrate the feasibility of using diffuse reflectance NIR-spectroscopy for the noninvasive measurement of blood glucose. |
| Databáze: | OpenAIRE |
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