Design and Synthesis of Pironetin Analogue/Combretastatin A-4 Hybrids and Evaluation of Their Cytotoxic Activity

Autor:	Juan Murga, Santiago Díaz-Oltra, J. Alberto Marco, Concepción Vilanova, Eva Falomir, Miguel Carda, Sandra Torijano-Gutiérrez
Rok vydání:	2014
Předmět:	Combretastatin A-4 Combretastatin chemistry.chemical_compound chemistry Stereochemistry Organic Chemistry Cytotoxic T cell Molecule Moiety Physical and Theoretical Chemistry Cytotoxicity Variable length
Zdroj:	European Journal of Organic Chemistry. 2014:2284-2296
ISSN:	1434-193X
DOI:	10.1002/ejoc.201301725
Popis:	We describe the preparation of a series of hybrid molecules containing a combretastatin A-4 moiety and a pironetin analogue fragment linked by an ester spacer of variable length. The cytotoxic activities of these compounds have been measured and the relationship between the structure and cytotoxicity is discussed. Some of the tested compounds showed cytotoxicity values of the same order of magnitude as those of the parental molecules, combretastatin A-4 and pironetin, and were less toxic than the latter for normal cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::102e4ed09d16e25633503594abb630b0 https://doi.org/10.1002/ejoc.201301725 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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