Antiviral activities of ellagitannins against bovine herpesvirus-1, suid alphaherpesvirus-1 and caprine herpesvirus-1
| Autor: | Angel S. Galabov, Stéphane Quideau, Neli Vilhelmova-Ilieva, Ivo Sirakov, Rémi Jacquet |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Grandinin
0303 health sciences Veterinary medicine biology Strain (chemistry) 040301 veterinary sciences viruses 04 agricultural and veterinary sciences biology.organism_classification Virology In vitro Bovine herpesvirus 1 030308 mycology & parasitology 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound chemistry Cell culture Suid alphaherpesvirus 1 Cytopathic effect Castalagin |
| Zdroj: | Journal of Veterinary Medicine and Animal Health. 12:139-143 |
| ISSN: | 2141-2529 |
| DOI: | 10.5897/jvmah2020.0857 |
| Popis: | In vitro antiviral activity of three ellagitannins - castalagin, vescalagin and grandinin was investigated against replication of three of the most common herpes viruses infecting animals, namely bovine herpesvirus-1 (BoHV-1), suid alphaherpesvirus-1 (SuHV-1), and caprine herpesvirus-1 (CapHV-1). The cytopathic effect inhibition test via the neutral red uptake assay in Madin-Darby bovine kidney (MDBK) cell culture was applied. The highest activity was demonstrated by castalagin followed by vescalagin against replication of SuHV-1, strain A2, with selectivity index values of 336.8 and 309, respectively, which are close to that of acyclovir (SI = 540). The activity of grandinin against the replication of SuHV-1 A2 strain (SI = 40.8) as well as the activity of all three substances against the replication of BoHV-1 strain K22 was lower but still significant (castalagin SI = 45; vescalagin SI = 42.5; grandinin SI = 32.3). Against the E/CH strain of CapHV-1, the three ellagitannins showed a moderate to weak activity: Castalagin SI = 19.3, vescalagin SI = 18.8, grandinin SI = 11.8. The results obtained characterize compounds tested as perspective antivirals. Key words: bovine herpesvirus-1, suid alphaherpesvirus-1, caprine herpesvirus-1, ellagitannins, alpha acyclovir, antiviral activity. |
| Databáze: | OpenAIRE |
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