A new haemoglobin variant: Haemoglobin anantharaj alpha 11 (A9) lysine → glutamic acid

Autor:	S. Na-Nakorn, Sa-nga Pootrakul, S. Suanpan, B. Kematorn
Rok vydání:	1975
Předmět:	chemistry.chemical_classification Mutation Lysine Alpha (ethology) Heterozygote advantage Glutamic acid Iron deficiency Biology medicine.disease_cause medicine.disease Biochemistry Genetics and Molecular Biology (miscellaneous) Amino acid Starch gel electrophoresis Biochemistry chemistry medicine
Zdroj:	Biochimica et Biophysica Acta (BBA) - Protein Structure. 405:161-166
ISSN:	0005-2795
DOI:	10.1016/0005-2795(75)90326-8
Popis:	Four heterozygotes for a fast α-chain variant in a Thai family were detected on starch gel electrophoresis during a survey study on iron deficiency anaemia in a rural area not far from Bangkok. They were healthy and had normal haematological profiles except for the presence of around 44% abnormal pigment, quantitated by cellulose acetate electrophoresis. The structural characterization of the variant by globin chain separation, peptide mapping, and amino acid analyses of the abnormal peptides indicated that lysine residue 11 (A9) of α-chain was replaced by glutamic acid. This mutation has not been previously described and it is proposed that it be called Haemoglobin Anantharaj.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::102b62545ce463387ebd3206915bccec https://doi.org/10.1016/0005-2795(75)90326-8 Zobrazit plný text záznamu