Effects of Acute Administration of Naltrexone on Cardiovascular Function, Body Temperature, Body Weight and Serum Concentrations of Liver Enzymes in Autistic Children

Autor:	Appelgate K, A. Arthur-Smith, M. K. Hammock, Herman Bh, Kuehl K
Rok vydání:	1989
Předmět:	medicine.medical_specialty business.industry Antagonist Placebo Naltrexone Transaminase Blood pressure Endocrinology Oral administration Internal medicine Heart rate medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Opiate business medicine.drug
Zdroj:	Developmental Pharmacology and Therapeutics. 12:118-127
ISSN:	2504-2505 0379-8305
DOI:	10.1159/000480957
Popis:	The effects of acute, orally administered naltrexone (0.5, 1.0, 1.5 and 2.0 mg/kg), a potent opiate receptor antagonist, on auscultated heart rate, systolic blood pressure and axillary body temperature were investigated before and about 1 h postdrug in 5 autistic children (4-12 years of age). In addition, an electrocardiogram was recorded on each child before and about 3 h after placebo or 2.0 mg/kg of naltrexone. Finally, the serum concentrations of the liver enzymes glutamic-oxaloacetic transaminase (SGOT) and glutamic-pyruvic transaminase (SGPT) were measured 24 h following placebo or naltrexone administration. Naltrexone had no statistically significant effects on any of these measures in comparison with baseline or placebo levels. Thus, these data provide preliminary evidence for the safety of acute administration of naltrexone in children.
Databáze:	OpenAIRE
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