ChemInform Abstract: The Chemistry of Pseudomonic Acid. Part 10. Preparation of Heterocyclic Derivatives

Autor:	Graham Walker, Peter J. O'hanlon, Norman H. Rogers, Michael John Crimmin
Rok vydání:	1990
Předmět:	chemistry.chemical_compound chemistry Pseudomonic acid Organic chemistry Stereoselectivity General Medicine Phosphonate Heterocyclic derivatives
Zdroj:	ChemInform. 21
ISSN:	0931-7597
DOI:	10.1002/chin.199008331
Popis:	The preparation of a large variety of normonyl heterocycles is described. Methods involving cyclisation of monic acid derivatives gave access to only a limited number of types of heterocycles. Olefination methods proved to be of wider applicability with phosphonate stabilised anions providing the biologically active E-isomer in a 3–4 : 1 excess. The Peterson type olefination proved to be the most useful method with the largest range of heterocycles and stereoselectivity of E:Z 4 to >10 : 1.
Databáze:	OpenAIRE
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