Effects of generally recognized as safe (GRAS) and dietary compounds on phenylephrine metabolism in LS180 human intestinal cells
| Autor: | Zhenxian Zhang, Phillip M. Gerk |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pharmacology
Zingerone Pterostilbene Pharmaceutical Science General Medicine 030226 pharmacology & pharmacy Bioavailability Eugenol 03 medical and health sciences chemistry.chemical_compound Isoeugenol 0302 clinical medicine chemistry 030220 oncology & carcinogenesis Generally recognized as safe medicine Pharmacology (medical) Phenylephrine Propylparaben medicine.drug |
| Zdroj: | Biopharmaceutics & Drug Disposition. 39:443-447 |
| ISSN: | 0142-2782 |
| Popis: | Phenylephrine (PE) has low and variable oral bioavailability in humans, due in part to presystemic metabolism by sulfation. LS180 cells were used as a model of the human intestinal epithelium to examine phenylephrine metabolism and its inhibition by generally recognized as safe (GRAS) and dietary compounds. Curcumin, zingerone, resveratrol, guaiacol, pterostilbene and isoeugenol significantly inhibited phenylephrine disappearance, while vanillin, propylparaben and eugenol did not. However, when propylparaben was combined with either vanillin or eugenol, the phenylephrine disappearance was significantly inhibited. These data suggest that these compounds or combinations thereof may have potential to improve phenylephrine oral bioavailability. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text