Autonomic, Cardiovascular, and Respiratory Responses to Hyperglycemic Stimulus in Healthy Subjects

Autor: Alejandra Guillen-Mandujano, Salvador Carrasco-Sosa
Rok vydání: 2018
Předmět:
Zdroj: CinC
ISSN: 2325-887X
DOI: 10.22489/cinc.2018.026
Popis: In ten healthy subjects we assessed the effects of hyperglycemia, provoked by the ingestion of 75 g of glucose on: R-R intervals (RR), systolic pressure (SP), diastolic pressure (DP), respiratory frequency (RF) and tidal volume (V T ) 5-min time series; the time course of their low-frequency (LF RR , LF SP , LF DP ), high-frequency (HF RR , HF DP , HF Res ) powers and their central frequencies (cfLF DP , cfHF RR , cfHF DP ), computed by a time-frequency distribution; baroreflex (BRS) and respiratory sinus arrhythmia sensitivities (RSAS), obtained by alpha index and their coherences (cBRS and cRSAS) by cross time-frequency analysis. In relation to control, in hyperglycemia (peak of 143±12 mg/100 ml, p RR , LF DP , HF RR , HF Res , BRS, cBRS, RR, DP and V T decreased (p DP , cfHF RR , RSAS, cRSAS and RF increased (p SP and SP were similar. Our findings outline an integrative dynamic response to hyperglycemia characterized by: vagal activity inhibition associated to RR shortening; sympathetic outflow inhibition associated to reduced DP, which, via baroreflex with reduced sensitivity and input-output coupling degree, reinforces the vagal reduction; and respiratory activity modification associated to V T decrease, RF increase and improved respiratory modulation of cardiovascular function.
Databáze: OpenAIRE