A novel dinuclear Pd(II) complex dibridged by 2,2-iminodibenzoic acid: Synthesis, characterization, and biological activity
| Autor: | Jing Ge, Wanzhong Zhang, Hai-Tao Jin, Si-Jia Liu, En-Jun Gao, Fu-Chen Zhao, Xiao-Yu Ma, Yaguang Sun, B. Wang, Mingchang Zhu, Yang Meng |
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| Rok vydání: | 2016 |
| Předmět: |
Gel electrophoresis
010405 organic chemistry Stereochemistry General Chemical Engineering Infrared spectroscopy Biological activity General Chemistry 010402 general chemistry Cleavage (embryo) 01 natural sciences Fluorescence 0104 chemical sciences chemistry.chemical_compound chemistry Cleave Ethidium bromide DNA |
| Zdroj: | Russian Journal of Coordination Chemistry. 42:749-754 |
| ISSN: | 1608-3318 1070-3284 |
| DOI: | 10.1134/s1070328416110038 |
| Popis: | The novel dinuclear complex [Pd2(L)2(Phen)2] (Phen = 1,10-phenanthroline, H2L = 2,2'-iminodibenzoic acid) was synthesized and characterized by IR spectra, element analysis, and X-ray single-crystal diffraction (СIF file CCDC no. 1469344). The competitive binding study with ethidium bromide (EtBr) was tested by fluorescence measurement. The result indicated that the complex has an ability to displace the EtBr bound to DNA. Gel electrophoresis assay demonstrated the ability of the complex to cleave the HL-60 DNA. Apoptotic research indicated that [Pd2(L)2(Phen)2] exhibited significant cancer cell inhibitory rate. |
| Databáze: | OpenAIRE |
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