Study of the in vitro Activity of New Cephalosporins on Strains of Neisseria gonorrhoeaeof the Toulouse Region
| Autor: | J.C. Lefèvre, M.B. Lareng, M.F. Prère |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Pharmacology
Cefotaxime business.industry Cefazolin General Medicine biochemical phenomena metabolism and nutrition Microbiology Penicillin Cefotiam Infectious Diseases Oncology Ampicillin Drug Discovery polycyclic compounds medicine Ceftriaxone Pharmacology (medical) Cefoxitin business medicine.drug Moxalactam |
| Zdroj: | Chemotherapy. 27:15-18 |
| ISSN: | 1421-9794 0009-3157 |
| DOI: | 10.1159/000238023 |
| Popis: | The study was carried out with 50 strains of gonococci. Susceptibility to the antibiotics was determined by standard sensitivity test, by systematic test for β-lactamase and by measurement of the MICs. The cephalosporins tested were: moxalactam, cefotaxime, ceftriaxone, cefotiam, cefoxitin, cefazolin and cephalothin. Their activities were also compared with other β-lactams, namely penicillin and ampicillin. The efficacy in vitro of the cephalosporins: in the lead, ceftriaxone, remarkably active, with cefotaxime following very close, and then moxalactam with cefotiam a little behind, and finally all the other β-lactams tested. The median MICs of the new cephalosporins (moxalactam, cefotaxime, ceftriaxone and cefotiam) were at least 10 times greater than those of the other β-lactams tested. The MIC values observed with a resistant strain (penicillin, ampicillin; MIC 256 μg/ml) never exceed the maximum values found with the 50 susceptible strains. |
| Databáze: | OpenAIRE |
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