Dynamic characteristics of laser-Doppler flux in normal individuals and patients with Raynaud’s phenomenon before and after treatment with nifedipine under different thermal conditions
| Autor: | Henri Boccalon, K. O. Möller, P. Leger, A. Mineva, D. Popivanov, P. Bendayan |
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| Rok vydání: | 1999 |
| Předmět: |
Correlation dimension
medicine.medical_specialty integumentary system business.industry Biomedical Engineering Biophysics Health Informatics Bioengineering Laser Doppler velocimetry medicine.disease Surgery Biomaterials Clinical Practice Laser doppler flux Nifedipine Raynaud's disease Internal medicine medicine Cardiology In patient business After treatment Information Systems medicine.drug |
| Zdroj: | Technology and Health Care. 7:193-203 |
| ISSN: | 1878-7401 0928-7329 |
| DOI: | 10.3233/thc-1999-72-310 |
| Popis: | The study was aimed at choosing an appropriate characteristic of laser-Doppler flux (LDF) data for (1) distinguishing patients with Raynauds disease from normal controls and (2) evaluating the effect of nifedipine under different thermal conditions. We checked the reliability of three characteristics of nonlinear dynamics as statistical dimension D_s, correlation dimension D_2 and power-law index PLI. Their values depended heavily on the thermal condition. The most reliable characteristics that enabled us to distinguish the patients from normal controls and the effect of nifedipine under definite thermal condition proved to be D_s and PLI. The latter is simple for computation and is thus recommendable for clinical practice. D_s and PLI were higher in patients with Raynauds compared to normal controls and diminished during the transitions from low to high temperature. However, the characteristics used were unable to distinguish significantly Raynauds I from Raynauds II patients. |
| Databáze: | OpenAIRE |
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