Tetrakis(1-3-diazinane-2-thione)platinum(II) chloride monohydrate complex: Synthesis, spectroscopic characterization, crystal structure and in vitro cytotoxic activity against A549, MCF7, HCT15 and HeLa human cancer lines

Autor:	A. Zainelabdeen A. Mustafa, Anvarhusein A. Isab, Gaurav Bhatia, Mohammed Fettouhi, Muhammad Altaf, Mohammed I.M. Wazeer, Vikram Dhuna, Muhammad Monim-ul-Mehboob, Kshitija Dhuna
Rok vydání:	2014
Předmět:	Cisplatin biology Chemistry Stereochemistry Crystal structure Carbon-13 NMR biology.organism_classification In vitro Inorganic Chemistry HeLa chemistry.chemical_compound Platinum(II) chloride Materials Chemistry medicine Cytotoxic T cell Physical and Theoretical Chemistry Cytotoxicity medicine.drug
Zdroj:	Inorganic Chemistry Communications. 44:159-163
ISSN:	1387-7003
DOI:	10.1016/j.inoche.2014.03.020
Popis:	This communication reports on the synthesis, crystal structure and anticancer activities of a new Pt(II) complex [Pt(Diaz)4]Cl2 · H2O of a heterocyclic thione, where Diaz = 1,3-diazinane-2-thione. Solid state 195Pt, 15N and 13C NMR are also reported along with other spectroscopic data. The cytotoxic evaluation of the complex against A549, MCF7, HCT15 and HeLa human cancer lines is reported. The title compound was found to be a better cytotoxic agent against MCF7 than cisplatin.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0fd718eeb02a8bbe943239e48c5b8cb8 https://doi.org/10.1016/j.inoche.2014.03.020 Zobrazit plný text záznamu Full Text from ScienceDirect