Ticlopidine inhibits activation of mitogen-activated protein kinase by platelet-derived growth factor in cultured rat renal mesangial cells
| Autor: | Kazuki Nagasawa, Teruyoshi Yokoyama, Masako Nomiyama, Noriaki Ohnishi |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Platelet-derived growth factor
DNA synthesis Physiology Kinase Growth factor medicine.medical_treatment Biology Molecular biology chemistry.chemical_compound chemistry Nephrology Physiology (medical) Mitogen-activated protein kinase biology.protein medicine Ticlopidine Platelet-derived growth factor receptor Fetal bovine serum medicine.drug |
| Zdroj: | Clinical and Experimental Nephrology. 2:117-123 |
| ISSN: | 1437-7799 1342-1751 |
| DOI: | 10.1007/bf02479932 |
| Popis: | Background We previously found that ticlopidine inhibits the proliferation of cultured rat mesangial cells that is induced by fetal bovine serum. This study was designed to examine the effects of ticlopidine on platelet-derived growth factor (PDGF)-induced DNA synthesis and mitogen-activated protein (MAP) kinase activation in such mesangial cells to clarify the mechanism of the antiproliferative action. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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