COVID-19–Associated Hepatitis Complicating Recent Living Donor Liver Transplantation
| Autor: | Elizabeth C. Verna, Mercedes Martinez, Jay H. Lefkowitch, Adam Griesemer, Simona De Michele, Michael Lee, Jean C. Emond, Stephen M. Lagana, Sheryl Tulin-Silver |
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| Rok vydání: | 2020 |
| Předmět: |
Hepatitis
medicine.medical_specialty Respiratory distress medicine.diagnostic_test Coronavirus disease 2019 (COVID-19) business.industry Inflammation General Medicine 030230 surgery medicine.disease Gastroenterology Pathology and Forensic Medicine 03 medical and health sciences Medical Laboratory Technology 0302 clinical medicine Biliary atresia Apoptosis Internal medicine Liver biopsy medicine 030211 gastroenterology & hepatology medicine.symptom business Liver function tests |
| Zdroj: | Archives of Pathology & Laboratory Medicine. 144:929-932 |
| ISSN: | 1543-2165 0003-9985 |
| Popis: | We present a case of COVID-19 hepatitis in a living donor liver allograft recipient whose donor subsequently tested positive for COVID-19. The patient is a female infant with biliary atresia (failed Kasai procedure). She recovered well, with improving liver function tests for 4 days. On postoperative day 4 the patient developed respiratory distress and fever. COVID-19 testing (polymerase chain reaction) was positive. Liver function test results increased approximately 5-fold. Liver biopsy showed moderate acute hepatitis with prominent clusters of apoptotic hepatocytes and associated cellular debris. Lobular lymphohistiocytic inflammation was noted. Typical portal features of mild to moderate acute cellular rejection were also noted. |
| Databáze: | OpenAIRE |
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