Effects of long-chains of zwitterionic micelles on binding constants of triflusal and acetylsalicylic acid

Autor:	Fernando Martínez Martínez, C. del Valle, M. Ferrit
Rok vydání:	2009
Předmět:	Liaison Chemistry Alkaline hydrolysis (body disposal) Medicinal chemistry Micelle Hydrophobic effect Hydrolysis Colloid and Surface Chemistry Pulmonary surfactant Solubilization medicine Organic chemistry Triflusal medicine.drug
Zdroj:	Colloids and Surfaces A: Physicochemical and Engineering Aspects. 345:26-30
ISSN:	0927-7757
DOI:	10.1016/j.colsurfa.2009.04.034
Popis:	A spectrophotometric study of the reaction of the alkaline hydrolysis of triflusal (TFL) and acetylsalicylic acid (ASA) in the presence of zwitterionic micelles was carried out, with the objective of determining the effects of the hydrophobic and electrostatic interactions on the micellar union of both drugs. A series of zwitterionic surfactants of alkyldimethylammonio propanesulfonate (SB3- n ) were used: decyldimethylammonio propanesulfonate (SB3-10), tetradecyldimethylammonio propanesulfonate (SB3-14), hexadecyldimethylammonio propanesulfonate (SB3-16). This reaction is inhibited at higher surfactant concentrations. The experimental data has been processed according to the micellar pseudophase model. The values of the binding constants of both drugs in the micelle ( K S ) determine the importance of the hydrophobic and electrostatic interactions in the micelle solubilization of both drugs.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0fbeb9bab43d0326d022d0c1c7d68895 https://doi.org/10.1016/j.colsurfa.2009.04.034 Zobrazit plný text záznamu Full Text from ScienceDirect