Combined Action of the Anticholinesterase Drug Aminostigmine and the Antidepressant Pyrazidole on Mnemonic Function in Rats and Mice

Autor:	Glushkov Robert G, S. D. Yuzhakov, V. A. Parshin, N. I. Andreeva, V. V. Asnina, M. A. Kalinkina
Rok vydání:	2005
Předmět:	Pharmacology Aminostigmine Chemistry Drug Discovery Pharmacology toxicology Conditioned reflex Antidepressant Anticholinesterase drug Passive avoidance Reference drug Anticholinesterase Agents
Zdroj:	Pharmaceutical Chemistry Journal. 39:4-7
ISSN:	1573-9031 0091-150X
DOI:	10.1007/s11094-005-0067-2
Popis:	The effect of aminostigmine alone and in combination with pyrazidole on mnemonic function in rats and mice was studied using passive avoidance conditioned reflex. Aminostigmine is comparable with the reference drug galanthamine in the ability to improve learning and memory, while the aminostigmine - pyrazidole combination even exceeds the reference drug in this respect. Pyrazidole also potentiates the antiamnesic effect of galanthamine. A combination of pyrazidole (possessing no anticholinesterase properties) with anticholinesterase agents can be useful for the complex treatment of dementia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0fb54556265ed865d3d5b595c5472843 https://doi.org/10.1007/s11094-005-0067-2 Zobrazit plný text záznamu Plný text ve formátu PDF