A new N-containing phenolic glycoside from Capsicum annuum L
| Autor: | Han Chang, Yong Luo, Changwei Song, Cheng Qin, Changyan Yu, Yun Liu, Xirong Luo, Lingjie Meng, Xinting Zhu, Yong Zhang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Circular dichroism 010405 organic chemistry Stereochemistry Organic Chemistry Sulforhodamine B Glycoside Plant Science 01 natural sciences Biochemistry In vitro 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Capsicum annuum chemistry IC50 Two-dimensional nuclear magnetic resonance spectroscopy Heteronuclear single quantum coherence spectroscopy |
| Zdroj: | Natural Product Research. 36:546-552 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2020.1789983 |
| Popis: | A new N-containing phenolic glycoside (1) and seven known compounds were isolated from the fruits of Capsicum annuum L. Their structures were elucidated by extensive spectroscopic methods including MS, 1D and 2D NMR (HSQC, HMBC, 1H-1H COSY, etc.). The stereo configuration of the new compound was determined by comparison of the experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 1-8 were evaluated in vitro for their cytotoxic activities against HCT-116 cell line using Sulforhodamine B (SRB) assay, and the result showed only compound 6 displayed a weak inhibitory activity against HCT-116 (IC50 = 22.5 ± 3.3 mmol/mL). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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