Low absolute CD4+ T cell counts in peripheral blood predict poor prognosis in patients with newly diagnosed multiple myeloma

Autor:	Yuanyuan Jin, Xiaoyan Qu, Si-Shu Zhao, Wu Yujie, Yan Gu, Qinglin Shi, Jianyong Li, Jie Ding, Chen Lijuan
Rok vydání:	2020
Předmět:	Cancer Research medicine.medical_specialty business.industry T cell Hematology Newly diagnosed T lymphocyte medicine.disease Gastroenterology Peripheral blood 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Internal medicine Medicine In patient business Multiple myeloma CD8 030215 immunology Lymphocyte subsets
Zdroj:	Leukemia & Lymphoma. 61:1869-1876
ISSN:	1029-2403 1042-8194
Popis:	The T lymphocyte system plays an active role in tumor immunosurveillance in multiple myeloma (MM), and abnormal T lymphocyte populations are often observed in patients with MM. In the current study, we evaluated the prognostic impact of abnormal T lymphocyte subset distributions in patients with newly diagnosed MM (NDMM). Between December 2012 to October 2016, 110 NDMM patients were included in this study. Multiparameter flow cytometry was applied to quantitatively analysis the peripheral blood T lymphocyte subsets, including CD4+ T cell, CD8+ T cell, and CD4/CD8 ratio. Survival analyses were performed based on the patients' clinical data and the quantity of T lymphocyte subsets. The median follow-up time was 27.0 months (range, 2.5-66). Baseline percentages and absolute CD4+ T cell counts and the CD4/CD8 ratio were positively correlated with both overall survival (OS) and progression-free survival (PFS) according to Kaplan-Meier curves (p < .05). In the multivariate COX analysis, lower CD4+ T cell count was an independent unfavorable factor in predicting both OS (p = .016) and PFS (p = .010). Furthermore, lower CD4/CD8 ratio was an independent adverse prognostic factor for shorter PFS (p = .017). These results suggested that T lymphocyte subsets were crucial indicators in correlation with MM patients' prognosis. Low CD4+ T cell counts and CD4/CD8 ratio were independent unfavorable prognostic predictors for patients with MM at diagnosis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0fa17173c3d23d8a2391f95b9ebf6b8e https://doi.org/10.1080/10428194.2020.1751840 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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