Lewis lung carcinoma variant with a high sensitivity to antitumor antiangiogenic therapy exhibits a high capacity for autophagy
| Autor: | O N Pyaskovskaya, N. V. Tregubova, D L Kolesnik, G I Solyanik |
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| Rok vydání: | 2012 |
| Předmět: |
Growth medium
animal structures urogenital system Autophagy Antiangiogenic therapy Lewis lung carcinoma Tumor cells Cell Biology Biology Agricultural and Biological Sciences (miscellaneous) chemistry.chemical_compound chemistry Biochemistry Genetics Cancer research Nutrient deficiency Incubation Cell survival |
| Zdroj: | Cytology and Genetics. 46:155-160 |
| ISSN: | 1934-9440 0095-4527 |
| DOI: | 10.3103/s009545271203005x |
| Popis: | This paper presents a comparative study of growth characteristics of two variants of Lewis lung carcinoma cells (LLC and LLC/R9) that were cultivated under conditions of nutrient deficiency caused by long-term incubation without changing the medium. It was found that LLC/R9 cells, which are characterized by high sensitivity to antitumor antiangiogenic therapy (AAT) compared to LLC cells, demonstrated a high dependence of cell survival on glucose levels in the growth medium, as well as an ability to activate autophagy under nutrient deprivation. It indicates that tumor sensitivity to AAT may be associated with the ability of tumor cells to induce autophagy under the conditions of nutrient substrate deprivation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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