The impact of preoperative breast biopsy on the risk of sentinel lymph node metastases: analysis of 2502 cases from the Austrian Sentinel Node Biopsy Study Group

Autor:	Christoph Tausch, F. Kugler, Peter Schrenk, P. Konstantiniuk, B Hoffmann, M. Jagoutz-Herzlinger, Anton Haid, C. Peters-Engl, S. Redtenbacher, S. Roka
Rok vydání:	2004
Předmět:	Breast biopsy Oncology Cancer Research medicine.medical_specialty Univariate analysis medicine.diagnostic_test business.industry Sentinel lymph node Sentinel node Fine-needle aspiration Internal medicine Relative risk Biopsy medicine Immunohistochemistry Radiology business
Zdroj:	Journal of Clinical Oncology. 22:562-562
ISSN:	1527-7755 0732-183X
DOI:	10.1200/jco.2004.22.90140.562
Popis:	562 Background: Preoperative breast biopsy might cause disaggregation of tumour cells and tumour cell spread. The purpose of this study was to investigate the impact of preoperative biopsy on the rate of metastases to the sentinel lymph node (SLN) of patients with primary breast cancer. Methods: We report the results of 2502 patients with primary breast cancer who were operated and a sentinel node biopsy was performed. The association of preoperative biopsy with the risk of SLN metastases was examined by regression analyses and tested for possible confounding well known factors for axillary node metastases. Results: 1892 Patients were available for final analyses. 1048 (55.4%) patients had a preoperative diagnosis done by fine needle aspiration or core biopsy. 642 (33.9%) patients had a positive SLN when conventional H&E and IHC staining was performed. Patients with preoperative breast biopsy showed a 1.37 fold (95% CI, 1.13–1.66) increased relative risk for SLN metastases on univariate analysis but this ...
Databáze:	OpenAIRE
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