ChemInform Abstract: Biocatalytic Approach to Enantiomerically Pure β-Amino Acids

Autor:	Valery P. Kukhar, Alexander E. Sorochinsky, Mariya V. Savchenko, A. V. Rybakova, Vadim A. Soloshonok, I.P. Shishkina, S. V. Galushko, Nataly A. Fokina, Vytas K. Švedas
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Penicillin Hydrolysis Enzyme chemistry Yield (chemistry) medicine Organic chemistry General Medicine Enantiomer Amino acid medicine.drug
Zdroj:	ChemInform. 27
ISSN:	0931-7597
DOI:	10.1002/chin.199601106
Popis:	β-Aryl-β-amino acids were prepared in good chemical yield and high enantiomeric purity (>95% ee) via penicillin acylase-catalyzed hydrolysis of the corresponding N-phenylacetyl derivatives. The (R)-enantiomers were the fast-reacting isomers in all cases studied. The biocatalytic procedure described employs very simple set of reactions using inexpensive commercially available chemicals and enzyme, and could be easily scaled up.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0f6e08502928f5c229d4e62561d17907 https://doi.org/10.1002/chin.199601106 Zobrazit plný text záznamu Plný text