New Approaches to Inhibition of Gastric Acid Secretion: Development and Mechanism of Omeprazole
| Autor: | Björn Wallmark |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
medicine.medical_specialty
biology business.industry Stomach digestive oral and skin physiology Hydrochloric acid Helicobacter pylori biology.organism_classification digestive system Gastroenterology digestive system diseases chemistry.chemical_compound medicine.anatomical_structure chemistry Internal medicine Duodenum medicine Gastric acid Secretion business Omeprazole medicine.drug Parietal cell |
| Zdroj: | Molecular and Cellular Mechanisms of H+ Transport ISBN: 9783642793035 |
| Popis: | With the exception of the secretory canaliculi of the parietal cell, the mammalian stomach is the most acidic compartment in the body, producing 140–160 mM hydrochloric acid. Fortunately, the oesophagus, the stomach and upper duodenum are well protected against acid attack and, in most healthy people, there is a balance between attacking and defending factors. Occasionally, this balance is disturbed, either by increased acid production, infection with Helicobacter pylori, or transient relaxation of the lower oesophageal sphincter. Whatever the precipitating factor, gastric acid is a key mediator of mucosal damage in diseases such as reflux oesophagitis and peptic ulcer. Furthermore, it is now well established that the most effective available methods of treating these diseases involve a reduction in gastric acid secretion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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