The Relationship between Maternal and Fetal CYP1A1 Genotype in Smokers and Nonsmokers to Benzo(a)pyrene Hemoglobin Adducts

Autor:	Christopher Cunningham, Steven R. Myers, Brooke Barnes, Terry Wright
Rok vydání:	2010
Předmět:	Fetus Polymers and Plastics Red Cell Chemistry Organic Chemistry Physiology Tobacco smoke Biomarker chemistry.chemical_compound Biochemistry Benzo(a)pyrene Genotype Materials Chemistry Hemoglobin Carcinogen
Zdroj:	Polycyclic Aromatic Compounds. 30:165-187
ISSN:	1563-5333 1040-6638
DOI:	10.1080/10406638.2010.483626
Popis:	Numerous methods exist by which we can follow exposure to tobacco smoke in experimental animals as well as in human populations. The simplest method to follow tobacco exposure is by assessing either urinary or serum cotinine levels. Although this provides an accurate assessment of short-term exposure to tobacco, it fails to provide a loan term assessment of exposure over several weeks and/or months. DNA adducts also provide effective means of monitoring exposure to tobacco smoke carcinogens. However, with the use of DNA adducts one deals with repair mechanisms, which may be altered as a result of the initial exposures. The ideal biomarker for use in assessing chemical exposures over a long-term basis is the use of the red cell protein hemoglobin. Formation of electrophilic metabolites of carcinogens has been shown to react with a variety of nucleophilic sites on hemoglobin, therefore forming covalent adducts which persists for the life of the red cell (120 days) and thus can be detected in used a...
Databáze:	OpenAIRE
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