Short-Term Glucosamine Infusion Does Not Affect Insulin Sensitivity in Humans1
| Autor: | Marie-Jose J. Pouwels, Cees J. Tack, Paul N. Span, Jos A. Lutterman, Paul Smits, Judith R. Jacobs |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism medicine.medical_treatment Glucose uptake Clinical Biochemistry Biochemistry chemistry.chemical_compound Endocrinology Insulin resistance Forearm Glucosamine medicine.artery Internal medicine Medicine Brachial artery Saline Pancreatic hormone business.industry Insulin Biochemistry (medical) medicine.disease carbohydrates (lipids) medicine.anatomical_structure chemistry lipids (amino acids peptides and proteins) business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 86:2099-2103 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.86.5.7470 |
| Popis: | Overactivity of the hexosamine biosynthetic pathway may underlie hyperglycemia-associated insulin resistance, but to date human studies are lacking. Hexosamine pathway activation can be mimicked by glucosamine (GlcN). In the present placebo-controlled study we determined whether GlcN infusion affects insulin resistance in vivo. In 18 healthy subjects, we applied the double forearm balance technique (infused arm vs. control arm) combined with the euglycemic hyperinsulinemic clamp (60 mU/m2·min insulin) for at least 300 min. During the clamp, subjects received infusions in the brachial artery of 4 μmol/dL·min GlcN from 90–240 min (n = 6) or from 0–300 min (n = 6) or saline (placebo; n = 6). We studied the effects of GlcN on forearm glucose uptake (FGU; infused arm vs. control arm, and vs. placebo experiments) and on whole body glucose uptake. GlcN infusion raised the plasma GlcN concentration in the infusion arms to 0.42 ± 0.14 and 0.81 ± 0.46 mmol/L; plasma GlcN remained very low ( |
| Databáze: | OpenAIRE |
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