18F-FDG PET/CT in ovarian cancer recurrence: Clinical impact, correlation with ceCT and CA-125, and prognostic value
| Autor: | P. García-Talavera, Andrea Verdú, Felipe Gómez-Caminero, Pilar Tamayo, Piedad Arias, Elena Alejo |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Receiver operating characteristic business.industry General Engineering medicine.disease Predictive value 030218 nuclear medicine & medical imaging Correlation 03 medical and health sciences 0302 clinical medicine medicine General Earth and Planetary Sciences Histopathology Fdg pet ct Radiology Ovarian cancer business Survival analysis General Environmental Science |
| Zdroj: | Revista Española de Medicina Nuclear e Imagen Molecular (English Edition). 40:207-213 |
| ISSN: | 2253-8089 |
| DOI: | 10.1016/j.remnie.2020.09.011 |
| Popis: | Aim To evaluate 18F-FDG-PET/CT for suspected ovarian cancer relapse with negative/inconclusive conventional imaging, or restaging potentially resectable ovarian cancer relapse. Material and methods Thirty-six cases and 140 locations were studied. PET/CT, ceCT and serum CA-125 was conducted in all cases. Nineteen cases were requested for restaging, 17 for suspected relapse. We compared ceCT and PET/CT, assessed by histopathology or radiological follow-up, calculating sensitivity (S) and positive predictive value (PPV) by cases and lesions. We evaluated the correlation between size, number, uptake of the lesions and CA-125. We conducted survival analysis, using ROC curves to calculate the optimal cut-off of SUVmax for survival prediction. We checked whether PET/CT modify the therapeutic attitude vs. conventional imaging. Results PET/CT and ceCT were concordant in 12 cases: 11 positives (30 lesions), all confirmed. There was 1 FN. In the 24 non-concordant, PET/CT was positive in 19 (97 lesions); ceCT in 21 (59 lesions); 54% of the lesions were concordant. Overall, PET/CT detected 127 lesions, with S = 97% and PPV = 100%. ceCT detected 89 lesions, with S = 61% and PPV = 90%. No significant correlation was found between CA-125 and the other parameters. PET/CT detected 10 positive cases, with normal CA-125. PET/CT modified therapeutic management in 15 cases. Significant differences were found in survival with SUVmax = 11.8 Conclusions PET/CT plays an important role in ovarian cancer relapse, with sensitivity and PPV higher than ceCT, modified therapeutic management in up to 42% of cases, and could be a valuable tool for predicting survival. |
| Databáze: | OpenAIRE |
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