Chiral Pyrrolidine Derivatives as Catalysts for the Enantioselective Addition of Diethylzinc to Aldehydes
| Autor: | Hiroko Inaba, Nobuo Ikota |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
inorganic chemicals
chemistry.chemical_classification Addition reaction organic chemicals Enantioselective synthesis General Chemistry General Medicine Diethylzinc Aldehyde Asymmetric induction Pyrrolidine Benzaldehyde chemistry.chemical_compound chemistry Drug Discovery health occupations polycyclic compounds Organic chemistry heterocyclic compounds Aliphatic compound |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 44:587-589 |
| ISSN: | 1347-5223 0009-2363 |
| Popis: | A chiral hydroxylated pyrrolidine derivative (4) and an N-(2-mercaptoethyl)pyrrolidine derivative (1c) were synthesized from D-ribonolactone and were used as chiral catalyst ligands in the reaction of diethylzinc and aldehydes. High asymmetric induction of up to 95% ee was observed in the addition to aromatic aldehydes using the chiral hydroxylated pyrrolidine derivative 4. |
| Databáze: | OpenAIRE |
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