Therapeutic effects of immune plasma in foals with Rhodococcus equi pneumonia

Autor: Ronald J. Martens, M. K. Chaffin, R. A. Fiske, J G Martens
Rok vydání: 2010
Předmět:
Zdroj: Equine Veterinary Journal. 23:23-29
ISSN: 2042-3306
0425-1644
Popis: Summary The immunotherapeutic efficacy of specific immune plasma was evaluated in pony foals infected experimentally with Rhodococcus equi. Viable R. equi were aerosolised into the right caudodorsal lung of 10 foals at seven days of age. Immune plasma, produced by repeated parenteral administration of viable R. equi to an adult donor gelding, was harvested and frozen. Group 1 (4 foals) and Group 2 (6 foals) foals received lactated Ringer's solution and immune plasma, respectively, at seven and nine days post infection. Clinical signs, haematological alterations, immune responses and thoracic radiographs were monitored throughout the study. All foals were destroyed and complete post mortem examinations were performed. All foals developed pneumonia as evidenced by clinical and radiographic alterations. Immune plasma had no significant effect on survival rate, length of survival, temperature response or peripheral blood concentrations of leucocytes, neutrophils or fibrinogen. Enzyme-linked immunosorbent assay values for R. equi-specific antibody and serum concentrations of IgG were significantly greater in Group 2 foals following treatment with immune plasma. Post mortem examination of three Group 1 and four Group 2 foals, destroyed because of terminal disease, revealed severe pyogranulomatous pneumonia. The two surviving Group 2 foals were free of gross pulmonary lesions and had minimal microscopic scar formation three months post infection; whereas the one surviving Group 1 foal had a large, encapsulated, caseonecrotic pulmonary mass three months post infection. This study demonstrates that the parenteral administration of R. equi immune plasma to foals seven days after experimental infection with R. equi does not alleviate the clinical signs nor alter the course of disease.
Databáze: OpenAIRE
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