Synthesis and self-assembly of amphiphilic precision glycomacromolecules

Autor:	Dimitri Wilms, Laura Hartmann, Julian Sindram, Marius Otten, Alexander Banger, Jessica Kania, Thomas C. Marlovits, Matthias Karg, Sean Miletic, Alexander K. Strzelczyk
Rok vydání:	2021
Předmět:	chemistry.chemical_classification Polymers and Plastics Chemistry Organic Chemistry Dispersity Bioengineering Polymer Adhesion Biochemistry Micelle Chemical engineering Amphiphile Side chain Self-assembly Macromolecule
Zdroj:	Polymer Chemistry. 12:4795-4802
ISSN:	1759-9962 1759-9954
Popis:	We present the synthesis of so called amphiphilic glycomacromolecules (APGs) by using solid-phase polymer synthesis. Based on tailor made building blocks, monodisperse APGs with varying compositions are synthesized, introducing carbohydrate side chains and crosslinkable units at defined positions within the macromolecule. Self-assembly of the APGs is characterized via spectroscopic as well as scattering techniques and reveals structural dependencies between APG composition and self-assembly behavior such as the formation of spherical vs. worm-like micelles. Furthermore, polymerizable units within the APGs allow for fixation of the self-assembled structures. Carbohydrate presenting micelles are then evaluated as inhibitors of bacterial adhesion demonstrating their potential for biomedical applications.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::0f4c9e59617e53626b6e6aefcfc62fb2 https://doi.org/10.1039/d1py00422k Zobrazit plný text záznamu