Incretin-Based Therapies for the Treatment of Type 2 Diabetes: Evaluation of the Risks and Benefits

Autor: Sherman, S. I., Drucker, D. J., Gorelick, F. S., Buse, J. B., Bergenstal, R. M., Sherwin, R. S.
Jazyk: angličtina
Rok vydání: 2010
DOI: 10.17615/kj4b-d081
Popis: Limited evidence suggests that GLP-I may also preserve ventricular function and improve outcomes in human subjects with heart failure or myocardial infarction (11,12). [...] both exenatide and liraglutide reduce blood pressure, body weight, and plasma lipid profiles in subjects with type 2 diabetes (13), raising the hope that longterm treatment with these agents may reduce the incidence of cardiovascular events.\n However, two safety issues have been raised - pancreatitis and medullary carcinoma of the thyroid.
Databáze: OpenAIRE