| Autor: |
Takuhiro Nishida, Takayuki Nakazaki, Akira Yoshida, Hiroshi Ishikawa, Tohru Nakagoe, Toshiyuki Ogawa, Takatoshi Shimoyama, Toshio Miura, Kazuya Yoshida, Masao Tomita, Teruhisa Shimizu, Hiroyuki Kusano |
| Rok vydání: |
1993 |
| Předmět: |
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| Zdroj: |
The journal of the Japanese Practical Surgeon Society. 54:1984-1991 |
| ISSN: |
0386-9776 |
| DOI: |
10.3919/ringe1963.54.1984 |
| Popis: |
In order to know in more detail the clinicopathological features of Crohn's disease (CD), the vascular patterns were morphologically investigated by microangiography of surgical specimens. Six patients with CD treated by surgical resection were subjected to this study. 1) Although the microangiographic pattern of CD varies with the histologic features, the morphological basis for the vascular change of CD were mainly vascular disarrangement by inflammatory reaction of lymphoid tissue. Hypervascularity with widening of the submucosa was considered to be the eariest form. Section through an aphthoid ulcer showed vascular convergence to a surface of the ulceration. 2) The variable vascuar patterns with abnormal vascularity disarranged by degrees of inflammatory response was observed in the cobblestone area. 3) The vessels in the area with thickening of the bowel wall were greatly altered, tortuous and irregularly narrowed by fibrosis of all layers, resulted with a lack of normal vascular patterns. 4) In the part of intestine with longitudinal ulceration, the vessels were severely altered across all layers of the bowel wall, as abnormality of the extra-intestinal vessels, i.e., a narrowing and/or abrupt of vasa recta. The vascular patterns of CD, in which the vessels of all layers were disarranged with the disproportionate proliferating inflammation, appeared to be an important factor affecting the improvement of the lesions. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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