Evaluation of interferon-induced transmembrane protein-3 (IFITM3) rs7478728 and rs3888188 polymorphisms and the risk of pulmonary tuberculosis
| Autor: | Gholamreza Bahari, Fatemeh Abedipour, Mohammad Naderi, Mohammad Hashemi, Maryam Rezaei, Mohsen Taheri |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Tuberculosis General Neuroscience 030106 microbiology Cancer General Medicine Odds ratio Biology medicine.disease Gastroenterology General Biochemistry Genetics and Molecular Biology Confidence interval 03 medical and health sciences 030104 developmental biology Sample size determination Polymorphism (computer science) Internal medicine Genotype Immunology medicine General Pharmacology Toxicology and Pharmaceutics Allele |
| Zdroj: | Biomedical Reports. 5:634-638 |
| ISSN: | 2049-9442 2049-9434 |
| DOI: | 10.3892/br.2016.763 |
| Popis: | The current study aimed to examine the possible association between the interferon-induced transmembrane protein-3 (IFITM3) gene polymorphisms and risk of pulmonary tuberculosis (PTB) in a sample population. This case-control study was conducted on 188 PTB patients and 169 healthy subjects. The rs7478728 and rs3888188 variants of IFITM3 were genotyped using polymerase chain reaction-restriction fragment length polymorphism. The findings showed no significant association between rs7478728 polymorphism and risk of PTB. Regarding rs3888188 polymorphism, the TG genotype as well as G allele significantly increased the risk of PTB [odds ratio (OR)=2.48, 95% confidence interval (CI): 1.42-4.53; P=0.002, and OR=2.26, 95% CI: 1.33-3.86; P=0.003, respectively]. In conclusion, the findings revealed that rs3888188 polymorphism increased the risk of PTB in a sample of Iranian population. Additional investigation with larger sample sizes and different ethnicities are needed to verify our findings. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|