| Popis: |
In this research, new coated carbon electrodes were constructed and used for the determination of Clopidogrel drug The electrodes were constructed by preparing ion-pair for (ClO) with Silicotungstic acid (STA) using di butyl phthalate (DBP) and tri Butylphosphate as a Binder. These electrodes showed good sensitivity towards ClO with linear range of (1.0 *10-7-1.0* 10-3) M for both, correlation coefficient, (0.9693 and 0.9881 ) for DBP and TBP respectively, the life time (25 and 23) days , optimum temperature range ( 25-55)oC and optimum pH range (1.4-3.7) for both electrodes , limit of detection (3.33 10-8 and 2.63 10-8) M, slope (30.19 and 24.08) mV/decade for CLO-AST DBP and TBP electrodes respectively. These electrodes were successfully applied for determination of CLO in pure and pharmaceutical preparation form (tablets) with recovery of 99.42 , 99.03 % for DBP and TBP respectively and Biological sample (Urine recovery of 99.47 , 99.24 % and serum with recovery of 99.26 , 98.72 % . for both DBP, TBP |
