Fully implantable optoelectronic systems for battery-free, multimodal operation in neuroscience research
| Autor: | Abraham Vázquez-Guardado, Siddharth Krishnan, Anthony Banks, Chad R. Haney, Irawati Kandela, John P. Leshock, Chun Ju Su, Emily A. Waters, Zhaoqian Xie, Tyler R. Ray, John A. Rogers, Vaishnavi Krishnamurthi, Philipp Gutruf, Debashis Chanda, Yonggang Huang, Yeshou Xu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Battery (electricity) Computer science business.industry media_common.quotation_subject Integrated circuit Optogenetics Neuromodulation (medicine) Electronic Optical and Magnetic Materials Power (physics) law.invention 03 medical and health sciences 030104 developmental biology 0302 clinical medicine law Optoelectronics Wireless Electrical and Electronic Engineering Function (engineering) business Instrumentation Energy harvesting 030217 neurology & neurosurgery media_common |
| Zdroj: | Nature Electronics. 1:652-660 |
| ISSN: | 2520-1131 |
| Popis: | Recently developed ultrasmall, fully implantable devices for optogenetic neuromodulation eliminate the physical tethers associated with conventional set-ups and avoid the bulky head-stages and batteries found in alternative wireless technologies. The resulting systems allow behavioural studies without motion constraints and enable experiments in a range of environments and contexts, such as social interactions. However, these devices are purely passive in their electronic design, thereby precluding any form of active control or programmability; independent operation of multiple devices, or of multiple active components in a single device, is, in particular, impossible. Here we report optoelectronic systems that, through developments in integrated circuit and antenna design, provide low-power operation, and position- and angle-independent wireless power harvesting, with full user-programmability over individual devices and collections of them. Furthermore, these integrated platforms have sizes and weights that are not significantly larger than those of previous, passive systems. Our results qualitatively expand options in output stabilization, intensity control and multimodal operation, with broad potential applications in neuroscience research and, in particular, the precise dissection of neural circuit function during unconstrained behavioural studies. An optoelectronic platform that operates at low power and uses position- and angle-independent wireless power harvesting can provide multimodal programmable control over optogenetic stimulation parameters. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink