QOL-28. Clinico-molecular correlates of quality of survival and neurocognitive outcomes in medulloblastoma; a meta-analysis of the SIOP-UKCCSG-PNET3 and HIT-SIOP-PNET4 trials

Autor: Mathilde Chevignard, Kim S Bull, James Holt, Bertie Harrington, Jemma Castle, Marie-Amelie Heng, Colin Kennedy, Francois Doz, Birgitta Lannering, Stefan Rutkowski, Maura Massimino, Simon Bailey, Adeoye Oyefiade, Donald Mabbott, Steven C Clifford†, Debbie Hicks†
Rok vydání: 2022
Předmět:
Zdroj: Neuro-Oncology. 24:i139-i140
ISSN: 1523-5866
1522-8517
DOI: 10.1093/neuonc/noac079.511
Popis: Determinants of survivorship outcomes are emerging from limited studies of medulloblastoma (MB) survivors. We undertook an integrated analysis of biological (tumour group, host genetics) and clinico-demographic features in patients treated on the SIOP-UKCCSG-PNET3 and HIT-SIOP-PNET4 clinical trials with available quality of survival (QoS) data (n=218), to determine key correlates of survivorship, and their clinical potential. Treatment/demographic factors and molecular subgroup (MBWNT, MBSHH, MBGrp3, MBGrp4) were assessed against health status, behavioural functioning, and health-related quality of life (HrQoL). In DNA from HIT-SIOP-PNET4 (n=74), 39 candidate SNPs with known modifying effects on neurocognitive outcomes (e.g., involved in oxidative stress/inflammation) were genotyped and assessed against Wechsler Intelligence Scale (WISC) scores. As expected, MBSHH was associated with improved HrQoL, but subgroup did not associate further with QoS outcomes. SIOP-UKCCSG-PNET3 patients receiving chemotherapy before craniospinal irradiation (CSI) had significantly lower health status (p=0.021) and behavioural functioning (p
Databáze: OpenAIRE
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