Effect of surgery on cardiac structure and function in mild primary hyperparathyroidism

Autor: Celina Franco, Jens Bollerslev, Thord Rosén, Kenneth Caidahl, Svante Jansson, Thor Ueland, Gunhild A. Isaksen, Anita Persson, Charlotte L. Mollerup
Rok vydání: 2011
Předmět:
Zdroj: Clinical Endocrinology. 74:174-180
ISSN: 0300-0664
Popis: Summary Context The cardiovascular (CV) risk profile is worsened in primary hyperparathyroidism (PHPT), and CV mortality is related to serum calcium levels. It is unknown whether CV mortality is increased in the most common form of PHPT and whether the increased CV risk is reversible after surgery. Objective To investigate reversibility of echocardiographic variables in patients with mild PHPT who were randomized to observation without surgery or operation, and followed for 2 years. Design/Setting/Patients Forty-nine patients (mean age 63 ± 7 years, 8 men) who had performed the 2-year visit in a randomized study on mild PHPT (serum calcium at baseline 2·65 ± 0·09 mm) (observation) vs 2·67 ± 0·06 mm (surgery) and where echocardiography had been performed, participated in the study. Results Calcium and parathyroid hormone (PTH) levels were normalized following surgery and were stable in the observation group. PTH levels at baseline were highly correlated with ventricular mass. Detailed echocardiography revealed a minor and borderline significant treatment effect of surgery on left ventricular mass index (LVMI) compared to observation (P = 0·066) and a significant 11% reduction in diastolic dimension of the interventricular septum (IVSd-mean) in the surgery group (P
Databáze: OpenAIRE
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